Synthesis of the ω-Brominated α-Trifluoroacetylcycloalkanones and their Isoxazole Derivatives
نویسندگان
چکیده
Este trabalho mostra as reações entre 2-trifluoracetil-1-metoxi-1-cicloalquenos (1a-1e) ou 2-trifluoracetilcicloalcanonas e bromo molecular, para produção de ω-bromo-2trifluoracetilcicloalcanonas (3a-3e, 4a). Ficou demonstrado que o grupo 2-trifluoracetil determina o sítio de bromação no C-omega, carbono vizinho à carbonila endocíclica. Os produtos 2-trifluoracetilcicloalcanonas e ω-bromo-α-trifluoracetilcicloalcanonas foram ciclocondensados com cloridrato de hidroxilamina, formando os respectivos 5-trifluormetil-5-hidroxido-3,4polimetileno-4,5-diidroisoxazóis (5c-5e e 6c-6e).
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